The Diet Review Zone

Posts Tagged ‘biology’

Chaga grows as a black cankerous mass on birch, dead or living. It may rarely be found on beech, elm, ash or hornbeam as well.

In Europe and Asia, chaga has been used for centuries to treat cancers of the heart and liver, digestive ailments, and tuberculosis. [121]

The traditional use was to peel the black skin of the mushroom and then boil it into a tea. Being a compact and easily portable medicinal made it very valuable to healers throughout history.

Today’s scientific focus on chaga extract is primarily as an anti-tumor remedy. In fact, it was approved in Russia as a cancer drug already in 1955, successfully used to treat cancers of the stomach, lungs, breasts and cervix. [122]

A 1998 study on chaga extract showed that it did inhibit growth of cervical cancer in a lab. [123] And a 1995 study reported both growth inhibition and death of melanoma cells, also in a lab (in vitro). [124, 25]

Further research has confirmed that some of the active compounds of Siberian chaga do decrease cancer cell growth. [125, 126]

Betulin is a medically active compound from the birch tree that gets concentrated in the black outer skin of the chaga mushroom, which has been found to contain 30% betulin, [127] whereas the inside of the chaga mushroom contains fungal lanostanes. It would therefore be suggested that chaga tea is better made from the whole mushroom, including the black skin.

The best chaga extracts are made not only from the whole mushroom fruit body but also the mycelia (“roots”), which contain more medically active protein compounds than the fruit bodies.

Other research has found chaga to possess powerful anti-viral properties. In 1996, two studies published results of inhibitory effects on both influenza virus [127] and HIV. [128] Considering the nature of viruses, the most likely scenario is that chaga works on viruses by enhancing the body’s own immune system, a theory confirmed by a paper published in 2002 and another in 2005. [25, 129] The same mechanism may explain the reported anti-inflammatory effect of chaga. [130]

Furthermore, alcohol extract of chaga mushroom has been found to lower blood sugar levels. [131] Chaga also demonstrates significant antioxidant properties that help protect the genetic integrity of the cells. [132, 133]

As an interesting anecdote that does not relate to human health but demonstrates the curative power of the Chaga mushroom, Paul Stamets mentions a Quebec arborist who uses a chaga poultice to cure chestnut blight. It not only cures the infection but the tree even becomes blight resistant after treatment. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any herb (or mushroom) except as advised by a licensed medical practitioner.

Credits: Thank you, Paul Stamets, for research references.

Dr. Markho Rafael has worked with natural health since finishing Chiropractic College in 1996. He currently focuses on medicinal mushrooms in cooperation with Cordyceps Reishi Extracts, LLC, a U.S. business offering Chaga Mushroom Extract and much more. For the research references to this article, go to the Siberian Chaga Extract page and click on any number indicating a reference.

In a fascinating broadcast on National Public Radio, internationally renowned medicinal mushroom expert Paul Stamets tells his story of discovering the medicinal potential of agarikon, an extremely rare and threatened species of wood conk that requires century-old trees to grow. Agarikon is today all but extinct in Europe, its remaining distribution limited to the old growth forests on the North American West Coast.

Knowing that mushrooms are susceptible to many of the same microbes as humans, how could it be, he asked himself, that this perennial wood conk managed to stay healthy for 50 years in the dripping wet rain forest without rotting? It must have a powerful immune system, he concluded, with potentially powerful medicinal compounds that could benefit humans.

To find agarikon in the wild, look for something reminiscent of a beehive on the ancient tree trunks of an old-growth forest. (You may view a picture of agarikon through the agarikon-link on this page.) Please keep in mind that agarikon is a rare and threatened species. Do not harvest it unless there’s a very good reason for doing so. But by all means, bring out your digital camera.

Using a proprietary extraction method on his organically cultivated agarikon, Stamets created an agarikon medicinal. He sent a sample of it to the Defense Department for testing within the BIO Shield Program, at a top security lab facility in Ft. Dietrich, Maryland. The BIO Shield Program is dedicated to finding remedies for use against bioterrorism threats and potential biological warfare agents, such as anthrax or smallpox.

Within this BIO Shield Program, tens of thousands of natural and manmade compounds have been tested for use against biological warfare pathogens. Drug discovery supervisor John Seacrest was happy to report on the radio show that the agarikon extract provided by Stamets had indeed been one of the few substances tested that had proved effective against smallpox related viruses.

Following this discovery, Paul Stamets now has a patent pending on a mushroom-derived anti-viral drug. One of his financial backers, Boston-based investor John Norris, bases his support in part on the fact that, as he says, not everyone is able or willing to be vaccinated against diseases such as smallpox.

It’s also worth mentioning that Mr. Norris is a former second in command in the FDA hierarchy, and he believes that through his joint venture with Paul Stamets, they could soon be selling several hundred million doses of the Stamets agarikon extract to the armies of the United States, U.K., and Germany.

That may still be a few years into the future, though. Paul Stamets new mushroom related anti-viral medicine first has to stand up to exhaustive testing, and then eventually be approved for release by the FDA.

Note: The above article is intended for informational purposes only. Agarikon has not been approved by the FDA for use as a medicinal. Never use any herbal or mushroom-product for medicinal purposes unless advice to do so by a licensed medical practitioner.

Reference: Banse, T., NPR Morning Edition, Smallpox Defense May Be Found in Mushrooms, August 4, 2005.

About the author: Dr. Rafael has worked in natural health since 1996, specializing in mycomedicinals. Click Agarikon Mushrooms for picture of agarikon, mushroom products, free mushroom articles, or to request unique copies of medicinal mushroom articles for your own web-site or magazine / ezine. Click Fomitopsis medicinal for scientific research references about agarikon.

The use of Reishi as an herbal remedy dates back longer than any other medicinal mushroom in historic literature. The first written record can be found in Shen Nong’s Herbal Classic, dating back two thousand years. Reishi (a.k.a. Ganoderma or Ling Zhi) is often considered a panacea ” cure-all ” in Traditional Chinese Medicine. While it may not be literally accurate to refer to Reishi as a cure-all, the fact that it appears to act as an inflammation modulator may be one of many reasons for its age-old veneration in the Orient.

In fact, Chinese medical practitioners have been prescribing Reishi extract for ages in cases of arthritis, bronchitis and other conditions involving any type of inflammation. Modern research in Asia as well as in America and Europe confirm the validity of these uses. Out of 19 papers used for this article, 17 reported positive results in the use or Reishi extract for arthritis. Only two were studies were inconclusive, both of which were conducted by the same research team. (1,2)

A U.S. based study conducted in 1993 showed that a water extract of Ganoderma lucidum (Reishi) exhibited “significant anti-inflammatory activity.” (4) Ten years later, an Indian research paper was published which stated that the use of Reishi extract helped decrease inflammation in acute edema by 56% and in chronic edema by 60%. (3) Using the “Article References” link on this page, you will find references to seven additional research articles that confirm Reishi extract as a powerful anti-inflammatory agent. (5,6,7,8,9,10,11)

Other Reishi studies have been performed which more directly relate to arthritis. A 2006 report by Kenneth Blum et al. provided support that clinical evidence demonstrates the effectiveness and safety of natural substances for joint health, such as glucosamine sulfate , chondroitin sulfate, and Ganoderma lucidum [Reishi]. (12)

Also that same year, a Chinese study by Xi Bao et al. came to the conclusion that Reishi plus another medicinal herbal remedy commonly used in China seemed to have a “beneficial immunomodulatory effect” on arthritis. (13)

The mechanism through which Reishi achieves this beneficial effect on arthritis was suggested in a study the following year, 2007, by Ho et al., which states that GL-PP [Ganoderma lucidum polysaccharide peptide] significantly inhibited the proliferation of RASF [Rheumatoid Arthritis Synovial Fibroblasts] (14)

Five additional studies are included in the references that report positive findings between Reishi and arthritis. (15,16,17) One goes so far as to state that Reishi shows favorable results when compared to prednisone, and is free from the side effects. (18) In extension of this, a separate study also found that not only was Reishi extract free of the side effects of prednisone, it could also help balance the existing side effects of prednisolone* such as cell toxicity and proteinuria. (*Prednisolone is the active compound of prednisone. The liver breaks down prednisone and converts it to prednisolone.) (19)

In conclusion, the majority of research on the use of Reishi extract for inflammation or arthritis appears to support its effectiveness. Please remember that it is very important to always consult a licensed medical doctor before using any herb for medicinal purposes.

Name clarification: The Japanese name Reishi includes many closely related species. By far the most prevalent is Ganoderma lucidum (Common Reishi or Red Reishi), a species rare in the U.S. but common in South East Asia. The English common name for Ganoderma lucidum is Varnished Conk. In China, its known as Ling Zhi.

Other related species that are often called “Reishi” include: “Hemlock Reishi” (Ganoderma tsugae),” which is common on hemlock trees in eastern U.S.; the Chinese species known as “Black Reishi” (Ganoderma sinense); another American species found on the west coast which is sometimes referred to as “Red Reishi” (Ganoderma resinaceum), although “Red Reishi” more often refers to G. lucidum in contrast to “Black Reishi,” G. sinense; and finally two Japanese species, one that is sometimes known as “Purple Reishi” Ganoderma japonicum, and one without any English name, Ganoderma neo-japonicum.

Although originating in the wild from fields northwest of Sao Paolo, Brazil, the cultivation of Agaricus blazei as a medicinal mushroom was originated in 1993 by Japanese mycologists.

The primary focus of research conducted on Agaricus extract has been devoted to its cancer combating potential, in particular in regards to uterocervical [25] and breast cancer.

One study reported that Agaricus extract contained a higher level of beta glucans than any other medicinal mushroom. So while not included in this article, it may be worthwhile to also look into beta glucan related research. [25]

Research on Agaricus extract against cancer cell cultures (in vitro) have yielded primarily negative results, but testing on live individuals (in vivo) have shown some positive results. What this tells us is that Agaricus blazei’s effect on cancer is by stimulating the immune system rather than killing off cancer cells directly. [135, 136, 137, 138, 139, 140]

In fact, one Japanese study from 2002 showed that when stimulated by Agaricus extract, macrophages would deliver a two punch knockout to cancer cells. (Macrophages are a type of white blood cells.) Eight hours after taking Agaricus extract, the patient’s macrophages excreted a cancer killing compound known as alpha tumor necrosis factor. Then four hours after that, the same macrophages excreted another compound specifically targeted to finish off the now weakened cancer cells. [141]

An additional cancer protective property of Agaricus extract is that it helps inhibit the production of aromatase, a human enzyme associated with breast cancer development. [142]

Both alcohol and water extracts of Agaricus blazei have been shown to contain important medicinal compounds, [143] particularly extracts of the mycelium (“roots”). [25]

In addition to showing promise as cancer medicine, Agaricus extract also demonstrates antibacterial properties. In one study, it was particularly effective against salmonella. [144]

Finally a few words of caution: One test in 2003 showed that Agaricus blazei grown in China contained a significantly larger amount of cadmium than Agaricus grown in the United States. [145]

Secondly, although Agaricus extract has demonstrated some powerful anti-cancer properties, it also contains a family of cancer-inducing compounds known as agaritines. (These are also found in button mushrooms, crimini mushrooms and portobellos.)

A paper by Stijve et al. published in 2003 reported that Paul Stamets’ Agaricus blazei extract, produced in Washington state, contained drastically less of the carcinogenic agaritines compared with samples from China or California by a factor of 8000% and 2000% respectively. [145]

“Years ago, Paul Stamets … developed methods that precluded agaritines, and Stijve et al. (2003) published a comparison of commercial products from the US, China, and Japan. All but [Paul Stamets] products contained significant amounts of agaritine.” [145]

A few additional areas of promising research on Agaricus extract are listed by Paul Stamets in his book Mycelium Running: Colorectal cancer; sarcoma; viruses; blood sugar; cholesterol. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any herb (or mushroom) except as advised by a licensed medical practitioner.

The unique flavor of the gourmet mushroom Lion’s Mane (Hericium erinaceus) is often compared to either lobster or shrimp. And modern science is now discovering that not only is it a culinary delicacy but it may also possess some unique medicinal properties, with its ability to stimulate nerve and myelin regeneration. [150, 151] In the book Mycelium Running, foremost American medicinal mushroom expert Paul Stamets suggests this may make Hericium erinaceus useful in a large number of neurological conditions, from multiple sclerosis and muscular dystrophy to Alzheimer’s and dementia. [134]

In the wild, Lion’s Mane Mushroom (Hericium erinaceus) grows on hardwood trees, especially oak, sycamore, maple, walnut and beech. It can be found throughout the temperate areas of the world, from North America and Europe to Japan and China.

The specific medicinal compounds under scientific scrutiny are called erinacines, which are relatively small organic molecules that can pass through the blood brain barrier. Of course, passing through the blood brain barrier is essential in order to effect healing on nerve tissue or myelin sheaths. [152, 153, 154]

There are currently two Japanese patents on different extracts of Hericium erinaceus. One was filed in the 1990’s for an extract named “Nerve Growth Stimulant Factor.” [150, 151] The other, filed in 2004, is for a water extraction process, yielding a product that is likewise used for nerve and myelin healing. [155]

In addition to its effect on nerve regeneration, Traditional Chinese Medicine (TCM) also prescribes Hericium erinaceus extract for stomach and digestive conditions, as well as cancers of the digestive tract and related organs.

Modern studies have affirmed the validity of this traditional application of Hericium erinaceus extract. One paper published in 1985 reported positive findings in the treatment of atrophic gastritis. Another from 1995 concluded that Hericium erinaceus had an ameliorating effect on hepatoma with an increased life expectancy for treated patients. [156]

To conclude, some additional areas where modern medical research has indicated that Hericium erinaceus extract may have a therapeutic effect include: Immune support [157]; inflammation [134]; antimicrobial against Aspergillus and Candida [158]; anti-tumoral [159]; stomach cancer. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Always consult a licensed medical practitioner before using any herb (or mushroom) for medicinal purposes.

Credit: Thank you to Paul Stamets for source material.